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a KO macrophages exhibited greater uptake of modified lipoproteins relative to macrophages from WT mice. We propose that the expression of AT1a receptor by BMDCs limits atherosclerosis in vivo. Keywords: angiotensin II type 1 receptor, atherosclerosis, bone marrow transplantation, kidney injury, renin systemAngiotensin II (Ang II) is a vasopressor octapeptide in the renin system (RAS), which is a major determinant of blood pressure (BP). The diverse actions of Ang II are mediated by several types of receptors expressed in a variety of target tissues. Two Ang II receptors have Roshe Run Outfit Men

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been identified in humans, AT1 (type I) and AT2 (type II).

Nike Roshe Run Drawing

Nike Roshe Run Drawing

Nike Roshe Run Drawing

Nike Roshe Run Drawing

produce inflammatory cytok.

Nike Roshe Run Drawing

Nike Roshe Run Drawing

In comparison, rodents express two AT1 receptor isoforms, Ang II type 1a (AT1a) and Ang II type 1b (AT1b). In rodents, BP and the pathophysiological effects of RAS are primarily mediated Roshe Run Nike Men

Nike Roshe Run Drawing

Nike Roshe Run Drawing

by the AT1a receptor. 1The role of RAS in the pathogenesis of cardiovascular end organ damages has been well characterized. Interestingly, clinical studies and animal experiments have demonstrated that inhibition of RAS with pharmacological agents such as angiotensin converting enzyme inhibitors and AT1 receptor blockers (ARBs), as well as genetic disruption of RAS signaling components, diminishes end organ damage, particularly atherosclerosis2, 3, 4 and kidney injury.

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5, 6 The mechanisms underlying these effects have been studied predominately in cells derived from a variety Nike Roshe Run Drawing of organs expressing AT1 receptors, such as blood vessel, heart and kidney cells. 7, 8AT1 receptors are also expressed by bone marrow derived cells (BMDCs), such as macrophages and T cells. 9 Ang II has been proposed to have pro atherogenic and pro inflammatory effects on BMDCs that might influence end organ injury. For example, signaling by AT1 receptors in macrophages and monocytes has been reported to activate pro inflammatory transcription factors,10 increase macrophage Ox LDL (low density lipoprotein) uptake,11 increase macrophage mediated modification of LDL,12, 13 generate oxidative stress,14 Nike Roshe Run Grey And White

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